Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells.

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Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells

T-cell mediated cytotoxic responses to H-Y antigen require co-recognition of H-Y and H-2 gene products. F1 mael stimulating cells and target cells express H-Y antigen in association with both parental H-2 haplotypes. However, F1 females primed in vivo and challenged in vitro with F1 male cells lyse male target cells of F1 and only one parental H-2 haplotype. Thus, (CBA X B10)F1 females sensitiz...

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In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice

C57BL/10 female mice were primed to the male specific antigen H-Y, either by grafting with syngeneic male tail skin or by i.p. injection of syngeneic male spleen cells. Primed female spleen cells, either unseparated or filtered through nylon wool to remove most of the B lymphocytes, were then cultured for 5 days in vitro with irradiated syngeneic male spleen cells and assayed against 51Cr-label...

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Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naïve and Sensitized BALB/c Mice

BACKGROUND The present study examines a hypothesis that short allergen-derived peptides may shift an Aspergillus fumigatus (Afu-) specific TH2 response towards a protective TH1. Five overlapping peptides (P1-P5) derived from Asp f1, a major allergen/antigen of Afu, were evaluated for prophylactic or therapeutic efficacy in BALB/c mice. METHODS To evaluate the prophylactic efficacy, peptides w...

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Monoclonal Macroglobulinemia in Nzb/nzw F1 Mice

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Weak anamnestic responses of inbred mice to Yersinia F1 genetic vaccine are overcome by boosting with F1 polypeptide while outbred mice remain nonresponsive.

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1977

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.146.2.606